Therapeutic effects of sesamolin on leukemia induced by WEHI-3B in model mice

Abstract Sesamolin is one of the lignans derived from sesame oil. It has demonstrated significant antioxidant, anti-aging, and anti-mutagenic properties. also reportedly augments natural killer (NK) cell lysis activity. We previously reported that sesamolin exerts anticancer effects in vitro induces enhanced NK cytolytic activity against tumor cells. Herein, we aimed to determine mechanism by which prevents retards tumorigenesis BALB/c mouse models leukemia induced murine (BALB/c) myelomonocytic WEHI-3B Banded neutrophils, myeloblasts, monocytic leukemic cells were more abundant model than normal mice. decreased number almost 60% mice vivo; additionally, positive control drug, vinblastine, similarly hindered neoplastic proliferation. Spleen samples ~ 4.5-fold heavier those obtained mice, whereas spleen treated with had a similar weight Moreover, twofold increase cytotoxic These results indicated anti-leukemic vivo.